Potential Issues With Virtual Populations When Applied to Nonlinear Quantitative Systems Pharmacology Models
نویسندگان
چکیده
منابع مشابه
Improving the Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models
21 Quantitative systems pharmacology (QSP) models aim to mechanistically describe 22 disease progression and predict the effects of existing therapies or novel 23 compounds on disease biomarkers or outcomes. For most drug development 24 applications, it is important to predict not only the mean response to the 25 intervention but also the inter-patient variability. In addition, given the comple...
متن کاملEfficient Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models.
Quantitative systems pharmacology models mechanistically describe a biological system and the effect of drug treatment on system behavior. Because these models rarely are identifiable from the available data, the uncertainty in physiological parameters may be sampled to create alternative parameterizations of the model, sometimes termed "virtual patients." In order to reproduce the statistics o...
متن کاملQuantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration
Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm. Success will require quantitative characterization of MPSs and mechanistic analysis of experimental findings sufficient to translate resulting insights from in vitro to in vivo. We descri...
متن کاملTowards Quantitative Systems Pharmacology Models of Chemotherapy‐Induced Neutropenia
Neutropenia is a serious toxic complication of chemotherapeutic treatment. For years, mathematical models have been developed to better predict hematological outcomes during chemotherapy in both the traditional pharmaceutical sciences and mathematical biology disciplines. An increasing number of quantitative systems pharmacology (QSP) models that combine systems approaches, physiology, and phar...
متن کاملFrequency‐Domain Response Analysis for Quantitative Systems Pharmacology Models
Drug dosing regimen can significantly impact drug effect and, thus, the success of treatments. Nevertheless, trial and error is still the most commonly used method by conventional pharmacometric approaches to optimize dosing regimen. In this tutorial, we utilize four distinct classes of quantitative systems pharmacology models to introduce frequency-domain response analysis, a method widely use...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CPT: Pharmacometrics & Systems Pharmacology
سال: 2020
ISSN: 2163-8306,2163-8306
DOI: 10.1002/psp4.12559